Several Studies Explore the Potential Benefits of Red Raspberries

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Eight studies –including human trials – explore potential for satiety, blood sugar control, and anti-inflammatory properties of raspberries

“We are excited about this new flurry of studies, which builds on previously published research aimed to better understand the potential health benefits of red raspberries,” said Tom Krugman, Executive Director of the National Processed Raspberry Council (NPRC).  “Our Council is committed to delivering the highest quality nutrition and health science that consumers can use to make informed choices when aiming for a healthy diet.”

While additional research, particularly in humans, is warranted, preliminary evidence from these studies suggests that the actions of essential nutrients, fiber, and polyphenolic phytochemicals found in red raspberries may play a role in supporting key metabolic functions, including anti-inflammatory, anti-oxidative and metabolic stabilizing activity. While this emerging research is promising, and contributes to the overall understanding of the health benefits of red raspberries, conclusions cannot be drawn at this time.

Blood Sugar Control

In this human trial, investigators from the Center for Nutrition Research at the Illinois Institute of Technology looked at two study groups: obese individuals with impaired fasting glucose and hyperinsulinemia (PreDM) and healthy weight individuals with normo-glycemia and insulinemia. Participants experienced a significant reduction in postprandial glucose when 2 cups (250g) of red raspberries were consumed with meals compared to no raspberries. The glucose lowering was accompanied with less insulin suggesting improved insulin sensitivity in individuals with pre-diabetes and insulin resistance.

  • Xiao, D. Huang, Y. Park, E. Edirisinghe, I. and Burton-Freeman, B. Red Raspberries and Insulin Action: Understanding the Role of Red Raspberry Consumption on Postprandial Metabolic Indices. The FASEB Journal, April 2017, 31 no. 1 Supplement 973.9. http://bit.ly/PostprandialMetabolicIndices 

Satiety

  • Huang, L. Xiao, D. Park, E. Edirisinghe, I. and Burton-Freeman, B. The Effect of Red Raspberry on Satiety. The FASEB Journal, April 2017, 31 no. 1 Supplement 794.8. http://bit.ly/RaspberriesSatiety

Gut Health

In an eight-week pilot study, researchers from the Institute for Food Safety and Health from the Illinois Institute of Technology examined the impact of consumption of red raspberry purée or fructo-oligosaccharide on the gut microbiota and the subsequent bioavailability of red raspberry polyphenols in healthy volunteers.  Consumption of the red raspberry puree and the fructo-oligiosaccharide for 4 weeks resulted in decreased Firmicutes and increased Bacteroidetes, which was more pronounced after red raspberry intake. Additionally, a type of bacteria called Akkermansia that has been associated with metabolic health was increased during red raspberry intake only. These preliminary results are promising. Further research is needed to support the hypothesis that the consumption of raspberry puree may change the composition of the gut microbiota.

  • Zhang, X. Sandhu, A. Schill, K. Edirisinghe, I. and Burton-Freeman, B. The Reciprocal Interactions between Red Raspberry Polyphenols and Gut Microbiome Composition: Preliminary Findings. The FASEB Journal, April 2017, 31 no. 1 Supplement 965.29. http://bit.ly/GutMicrobiomeComposition

Dr. Giuliana Noratto and colleagues of the Department of Food and Nutrition Science at Texas A&M University studied if dietary supplementation with red raspberries could modulate the fecal microbiota of obese mice with diabetes and dyslipidemia. In this animal study, raspberry supplementation was associated with higher levels of Lachnospiraceae – a family of bacteria that can be depleted during diseases of the intestinal tract, such as inflammatory bowel disease. These findings provide a basis for formulating hypotheses for conducting additional studies, particularly in human trials.

  • Noratto, G. Garcia-Mazcorro, J. Chew, B. and Mertens-Talcott, S. Dietary Supplementation with Raspberry Whole Fruit Modifies the Relative Abundance of Fecal Microbial Communities in Obese Diabetic (db/db) Mice. The FASEB Journal, April 2017, 31 no. 1 Supplement 965.19. http://bit.ly/MicrobialCommunities

Type 2 Diabetes

In an animal study, mice fed 5% freeze dried raspberry for 12 weeks, showed signs of improved insulin resistance and reduced inflammation in skeletal muscle while consuming a high-fat diet. These data corroborate a short-term study in humans reported by Xiao and colleagues at the same meeting supporting further work in humans to provide additional insight into these findings.

  • Min Du, Tiande Zou, Bo Wang, Xingwei Liang, and Mei-Jun Zhu. Raspberry intake reduces skeletal muscle lipid accumulation and improves insulin sensitivity in mice fed high fat diet. The FASEB Journal, April 2017, 31 no. 1 Supplement 972.19. http://bit.ly/MuscleLipidAccumulation

A research team from the University of Michigan studied the potential biologically active properties of red raspberries with in vitro assays including antioxidant and anti-inflammatory capacities. Follow-up research explored the potential relationship between feeding freeze-dried whole raspberry powder and cardiometabolic risk in obesity prone rats. Red raspberries were found to upregulate the expression of specific cardiac-protective molecular proteins (myocardial adiponectin, its receptor 2, and apolipoprotein E). Rats fed the red raspberries also experienced altered nicotinamide phosphoribosyltransferase mRNA, a protein associated with multiple functions in conditions related to obesity and type 2 diabetes.   More research is needed to determine if compounds in red raspberries play a role in human cardiometabolic pathways.

  • Kirakosyan, A. Seymour, EM. Gutierrez, E. and Bolling, S. Associations of Dietary Intakes of Red Raspberry Fruits with Risk of Type 2 Diabetes Mellitus. The FASEB Journal, April 2017, 31 no. 1 Supplement 973.4. http://bit.ly/RiskofType2Diabetes

Inflammation

In a mouse model, red raspberry supplementation of 5% dry feed weight was found to suppress inflammation and facilitate epithelium repair compared to mice with induced colitis (inflammation of the colon) and fed a standard chow diet.  These observations are not conclusive, and further research is needed to determine if red raspberry supplementation supports epithelial function in humans.

  • Bibi, S. Du, M. Kang, Y. Sun, X. Xue, Y. Soussa Moraes, LF. and Zhu, M. Dietary Red Raspberry Enhances Intestinal Epithelium Repair in Chronic Colitis. The FASEB Journal, April 2017, 31 no. 1 Supplement 972.19. http://bit.ly/IntestinalEptheliumRepair

Anthocyanin Profiles of Processed Raspberries

Anthocyanin profiles among common processed forms of raspberries (frozen, juice concentrate, seeded puree, and seedless puree) on the U.S. market were investigated. Thirty-four samples – both domestic and imported – were reviewed. Seven individual anthocyanins were identified in the samples. While anthocyanin profiles varied slightly, contents varied considerably. This may reflect differences in varieties, origins, processing methods among other influential factors.

  • Wu, X. Sun, J. Ahuja, J. Haytowitz, DB. Burton-Freeman, B. Chen, P. Pehrsson, PR. Anthocyanin profiles and contents in processed raspberries on the U.S. market. The FASEB Journal, April 2017, 31 no. 1 Supplement 454.6. http://bit.ly/AnthocyaninProfiles

 

 

 

Red Raspberry Research Abounds at 2016 Experimental Biology Conference

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Six New Studies Point to Red Raspberry’s Potential Anti-Inflammatory Properties and Role in Cardiovascular, Blood Glucose and Liver Function

SAN DIEGO, CA – A flurry of new research on red raspberries is set to be presented this week at the 2016 Experimental Biology conference in San Diego. Initial findings from six animal model studies reveal the potential effects of red raspberry consumption on cardiovascular disease risk reduction, maintaining normal blood glucose levels and liver function as well as potential anti-inflammatory effects related to bone health.

Recently, the January issue of Advances in Nutrition published a comprehensive review of the available scientific literature on the potential role of red raspberries in helping to reduce the risk of metabolically-based chronic diseases, including cardiovascular disease, diabetes mellitus, obesity, and Alzheimer’s disease: all of which share critical metabolic, oxidative and inflammatory links.

“The new research being presented at Experimental Biology contributes to the growing body of nutrition research around the potential role of red raspberries in helping to reduce the risk factors associated with metabolically-based chronic diseases,” said Tom Krugman, Executive Director of the National Processed Raspberry Council. “While further research in humans is needed, these animal studies provide important insights that will drive future research.”

Red raspberries contribute a number of valuable essential nutrients, including providing an excellent source of vitamin C and nine grams of fiber per cup. They are also among the few plant foods that provide a source of ellagitannins and anthocyanins in the same package. While in vitro and animal studies suggests that these phytochemicals may help to reduce risk for some chronic diseases, additional research is needed to test similar hypotheses and possible effects in human metabolism.

Animal and in vitro (cell) research on red raspberries being presented at Experimental Biology includes:

Cardiovascular

Dr. Ara Kirakosyan of the University of Michigan investigated the potential effects of red raspberry intake on obesity-prone rats.

  • Kirakosvan, A., et al. Cardioprotective Effects of Red Raspberries in Obesity-prone Rats. The FASEB Journal, April 2016, vol. 30, no. 1 Supplement lb284 http://tinyurl.com/zht8d5j

Metabolic Syndrome

Dr. Neil Shay and colleagues from the Food Science and Technology department of Oregon State University, studied the effects of red raspberries in mice fed a high-fat, high-sugar Western diet.

  • Shay, N.F., et al. Intake of Whole Raspberries and the Raspberry Phytochemicals, Ellagic Acid and Raspberry Ketone Reduces Adiposity, Improves Glucose Control and Changes Hepatic Gene Expression Profiles in High-fat Fed Mice. The FASEB Journal, April 2016, vol. 30 no. 1 Supplement 692.6 http://tinyurl.com/hs44hsb

Dr. Mei-Jun Zhu and colleagues at Washington State University looked at the potential effect of red raspberry consumption on metabolic syndrome in male mice with diet-induced obesity.

  • Zhu, M.J., et al. Dietary raspberries ameliorate metabolic syndromes in diet-induced obese mice. The FASEB Journal, April 2016 vol. 30 no. 1 Supplement 907.21 http://tinyurl.com/hgtav6x

Diabetes

Principal investigator Dr. Giuliana Noratto of the Department of Food and Nutrition Science at Texas A&M University studied the effects of red raspberry consumption on diabetes-related complications and heart disease in obese diabetic mice.

  • Noratto, G., et al. Effects of Raspberry Dietary Supplementation on Risk Biomarkers of Diabetes Related Complications and Heart Disease in Diabetic Mice The FASEB Journal, April 2016, vol. 30 no. 1 Supplement 692.23 http://tinyurl.com/jcrq5pr

Liver Function

Dr. Geoff Sasaki and colleagues at Oregon State University looked at the capacity for ellagic acid quercetin to bind to the peroxisome proliferator-activated receptor-alpha (PPARa).

  • Sasaki, G., et al., Ellagic Acid and Quercetin are High-Affinity Ligands of Human Peroxisome Proliferator-Activated Receptor Alpha in an In-Vitro Competitive Binding Assay. The FASEB Journal, April 2016, vol. 30 no. 1 Supplement 691.7 http://tinyurl.com/jconyn7

Inflammation and Bone Health

Dr. Amber Thomas, of the Department of Nutrition and Food Sciences at Texas Woman’s University and colleagues, using mouse macrophage cells, studied the anti-inflammatory effect of polyphenols in red raspberries in the production of osteoclasts, the cells associated with the breakdown of bone.

  • Thomas, A., et al. Inhibitory Effects of Red Raspberry Polyphenols on Osteoclastogenesis in RANKL-Stimulated RAW264.7 Murine Macrophages. The FASEB Journal, April 2016, vol. 30 no. 1 Supplement 691.31 http://tinyurl.com/zohm4pv

In the Spotlight: Raspberries in the Media

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As a direct result of the NPRC’s marketing efforts, processed raspberries and raspberry health benefits have achieved significant media exposure over the past few months, reaching consumers and trade professionals across the U.S. Take a look at a few examples!

 

Yahoo! News: Five Reasons You Should Eat More Raspberries

 

Fitness Magazine: Surprisingly Creative Ways to Cook with Frozen Fruit

 

Dallas Morning News, Eat This Not That: How to Handle the Holidays

 

Chicago Sun Times: Festive and Flavorful Gifts

 

Meal Makeover Moms: Frozen Raspberry & Mango Smoothie Bowl for a Healthy, Fiber-Rich Breakfast or Snack

 

Orlando Family Magazine: A Very Berry Sweet Valentine’s Day

 

All Day I Dream About Food: Raspberry Chocolate-Filled Cupcakes

 

Fresh Plaza: Scientific Study Reveals Health Benefits of Red Raspberries   

 

Red Raspberry Health News

handful of raspberries600

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Research studies funded by the National Processed Raspberry Council have been published and are helping us spread the word about the health-supporting qualities of red raspberries.

 

  • Scientific Study Review Reveals Health Promoting Potential of Red Raspberries

Components in red raspberries may have anti-inflammatory, anti-oxidative and metabolic stabilizing activity, according to a comprehensive review of the available scientific literature published in the January issue of Advances in Nutrition. These properties shed light on the potential role of red raspberries in helping to reduce the risk of metabolically-based chronic diseases, including cardiovascular disease, diabetes mellitus, obesity, and Alzheimer’s disease: all of which share critical metabolic, oxidative, inflammatory links. Read More Here

 

  • Recent Studies Shed Light on Compounds in Red Raspberries That May Reduce Certain Risk Factors

Red raspberries are naturally rich in polyphenols, and as a result of research recently published in Free Radical Biology and Medicine and The Journal of Functional Foods, scientists are now beginning to understand how and why these polyphenols may offer human health benefits.  According to researcher Dr. Alan Crozier, at the Department of Nutrition, University of California, Davis, “In order to further study the potential health benefits of red raspberry consumption, it is important to first understand how the body metabolizes raspberry polyphenols, and the mode of action of the bioactive compounds that underlie these potential protective effects. While current evidence is promising, additional long-term studies are needed to establish the role of berry polyphenols in the prevention of specific health conditions.” Read More Here